As mentioned, HA took a brief vacation while I worked hard on my disease modeling system for the Global Burden of Disease 2010 study. First, I thought I was writing a book about the methods, but as I wrote I realized more and more things that I would like to do differently implementing the methods. So then I switched to re-writing all of the implementation, which seemed like an ambitious 1 week project. Two months later, I’m very happy with the results, and they’re online just in time for my users to crunch many numbers.

Of course, there are still plenty of issues that are coming up, and I still have to get back to writing the book about this approach. But I miss the variety of the blogging, and I’m starting it back up, even if I have plenty of other writing responsibilities.

Also, I love the wisdom of the internet. Dear readers, here is the description of this integrative disease modeling book I’ve been working on. Does it sound like something you’ve seen before? I’ve found that the mathematics I’m using have been rediscovered many times in many fields, all of which I would like to know more about.

*Integrative systems modeling of disease in populations* is the first book-length treatment of model-based meta-analytic methods for descriptive epidemiology. It develops, from first principles, the system dynamics model which constitutes the theoretical foundation of Years Lived with Disability (YLD) estimation in burden of disease studies. This compartmental model of the progression of disease through a population has been used for over ten years in global health epidemiology in the popular generic disease modeling system DisMod II, distributed by the World Health Organization. However, until now, the description of the model and the methods behind the software have been scattered through the scientific literature in a loose collection of journal articles and operations manuals.

In addition to collecting the prior work on compartmental modeling of disease together in one place, this book significantly extends the model, by formally connecting the system dynamics model of disease progression to a statistical model of epidemiological rates, the kind that are calculated in descriptive epidemiological research and collected through systematic review. This combination of systems dynamics modeling and statistical model, which the author calls *integrative systems modeling* allows the model to integrate all available relevant data. Because advanced numerical algorithms are needed to fit these complex models, a section of the book provides the necessary background on Markov chain Monte Carlo (MCMC) computation.

Experience with the results of systematic review indicates that when all available relevant data is collected, it is often very *sparse* and very *noisy*. The integrative systems models developed in this book focus particularly on techniques for handling sparse, noisy data. The book explores statistical models for over-dispersed count data, covariate modeling to both explain systematic variation in epidemiological rate data and increase predictive accuracy for estimates for subpopulations where no data is available, and age-pattern modeling to systematically incorporate expert knowledge about how quickly epidemiological rates can vary as a function of age. It also develops a novel theory of age group modeling to address heterogeneity in age groups commonly found during systematic review.

The theoretical foundations of integrative systems modeling of disease in populations are complemented with a series of applications of the model to meta-analysis of more than a dozen different diseases. These practical applications provide a unique opportunity to see how the model performs in a variety of scenarios, and also demonstrate how the model performs when the model assumptions are violated, and how to work around model assumption violations.

The book concludes with a detailed description of the future directions for research in model-based meta-analysis of descriptive epidemiological data and integrative systems modeling for global health.